We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
9
Zinc may reduce long COVID symptoms
Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Oral supplement improves long COVID
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
Most Useful Reviews
9
Zinc improves wellbeing
This zinc is fantastic! After a month of use, I've experienced positive changes, especially regarding my chronic fatigue syndrome. My anxiety has lessened, cravings decreased, and my skin and nails have improved significantly. I feel healthier overall!
Read More
9
Significant improvement
I purchased this vitamin for my father, and he noticed considerable improvement in his chronic fatigue syndrome symptoms. It has alleviated bone pain, stress, and fatigue effectively.
Read More
7.5
Supports immunity
6 people found this helpful
I chose this zinc picolinate as it is quickly absorbed by the body. Zinc is essential for the immune system to function properly and plays a role in bone health, wound healing, and reducing age-related diseases. If this comment resonates with you, please give it a like.
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Synbiotics improve post-COVID fatigue
The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
Read More
8
Oral supplement improves long COVID
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
8
Beta-glucan improves cognitive fatigue
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Read More
8
Zinc's limited role in fatigue relief
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
This zinc is fantastic! After a month of use, I've experienced positive changes, especially regarding my chronic fatigue syndrome. My anxiety has lessened, cravings decreased, and my skin and nails have improved significantly. I feel healthier overall!
Read More
9
Significant improvement
I purchased this vitamin for my father, and he noticed considerable improvement in his chronic fatigue syndrome symptoms. It has alleviated bone pain, stress, and fatigue effectively.
Read More
7.5
Supports immunity
6 people found this helpful
I chose this zinc picolinate as it is quickly absorbed by the body. Zinc is essential for the immune system to function properly and plays a role in bone health, wound healing, and reducing age-related diseases. If this comment resonates with you, please give it a like.
Read More
7.5
Effective support
4 people found this helpful
This product is very effective for my chronic fatigue syndrome. Whenever I feel fatigued or unwell, I take it, and it significantly helps me feel better.
Read More
9
Reduces fatigue
3 people found this helpful
Zinc is essential for converting thyroid hormones and can prevent fatigue associated with hypothyroidism. After trying this zinc supplement, I found it beneficial before exploring other treatments. It truly worked for me.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
The potential benefits of zinc in managing Chronic Fatigue Syndrome (CFS) are not extensively supported by rigorous scientific evidence. Nonetheless, zinc is an essential mineral involved in numerous biological processes, including immune function and energy metabolism, which may indirectly influence symptoms associated with CFS. Some studies suggest that a deficiency in zinc could exacerbate fatigue or other symptoms, indicating that maintaining adequate levels might be beneficial for overall health and wellbeing.
However, it’s critical to approach zinc supplementation with caution. While some individuals may benefit from taking zinc, especially if they have a documented deficiency, excessive intake can lead to toxicity and adverse effects. Therefore, if you're considering zinc supplements as part of your strategy to manage CFS, it's essential to consult with a healthcare provider. They can help determine appropriate dosage and whether it’s the right move for your health situation, ensuring a balanced approach to your overall care plan.
Based on user reviews, many individuals report noticing positive changes in their Chronic Fatigue Syndrome (CFS) symptoms after approximately one month of using zinc supplements. For instance, one user mentioned feeling healthier overall and experiencing reduced anxiety after a month of use Read Review. Others noted significant improvements in fatigue levels and overall well-being within similar time frames. Another review highlighted that after a month, the user found relief from CFS symptoms and an overall improvement in health Read Review.
While individual responses may vary, the general consensus among users is that consistent daily use over a month tends to yield noticeable benefits, including increased energy and reduced fatigue. Ultimately, for those looking to manage their CFS more effectively, adhering to a regimen may prove both essential and beneficial in achieving desired outcomes Read Review.
The exploration of zinc and its potential benefits for Chronic Fatigue Syndrome (CFS) has led to various studies that tap into its various roles in health. Research indicates that patients suffering from CFS often exhibit lower levels of zinc compared to healthy individuals, and these lower levels correlate with greater severity of symptoms [7]. Furthermore, studies suggest that zinc may contribute to normalizing immune responses and offer improvements in clinical symptoms when combined with other therapies, although the precise effects of zinc alone are difficult to isolate due to the combination with other ingredients [6].
Moreover, one study involving a combination of zinc with melatonin suggested potential improvements in fatigue and quality of life among patients with Myalgic Encephalomyelitis (ME/CFS) [5]. Despite this, the role of zinc remains somewhat unclear as many studies incorporated different supplements, making it challenging to draw definitive conclusions about zinc's efficacy on its own. Overall, while there is some indication that zinc supplementation could support management of CFS symptoms, the complexity of its interactions necessitates further research to verify its isolated effects [4].
According to user reviews, many individuals have reported noticeable improvements in their chronic fatigue syndrome (CFS) symptoms after incorporating zinc supplements into their daily routine. One user observed a significant reduction in fatigue, bone pain, and stress levels, describing this supplement as a great relief for their father suffering from CFS Read Review. Another reviewer echoed similar sentiments, stating that the supplement significantly alleviates feelings of fatigue whenever they feel unwell Read Review.
Additionally, there are reports of enhanced overall well-being, with users noting improvements in skin health, nail strength, and even mood elevation Read Review. Consistent use has been attributed to a boost in energy levels, with one user stating that they experienced a definite increase in energy since starting the supplement Read Review. While these accounts are encouraging, it’s important to note that individual results can vary considerably based on personal health circumstances and consistency of use.
According to user reviews, many individuals have reported positive experiences when combining zinc supplements with other supplements to manage Chronic Fatigue Syndrome (CFS). One user mentioned that they purchased zinc picolinate along with magnesium to support hormone balance and thyroid function, noting that this combination had a positive impact on their CFS symptoms. Additionally, they highlighted that the magnesium helped manage restless legs at night, which contributed to better sleep and overall recovery Read Review.
Other users have also found that incorporating zinc into their routine enhances its effectiveness, particularly when combined with dietary adjustments or additional nutritional support. For example, one reviewer emphasized the importance of maintaining a consistent schedule for maximum results, suggesting that a holistic approach, including diet and other supplements, can yield better outcomes for those experiencing chronic fatigue Read Review. While individual results may vary, the overall sentiment among users is that a combination of supplements can support the management of CFS more effectively than zinc alone.
Users generally reported positive experiences with zinc supplementation for managing symptoms of Chronic Fatigue Syndrome (CFS). Many noted improvements in their overall health, energy levels, and a reduction in fatigue-related symptoms. For instance, one user mentioned feeling healthier and experiencing decreased cravings and anxiety after a month of using zinc (Read Review). Another user stated that taking zinc alleviated bone pain and stress while effectively reducing fatigue associated with their CFS (Read Review).
While specific dosage recommendations were not a frequent topic among reviews, it is evident that users found success by incorporating zinc into their daily routines. One user explicitly mentioned taking zinc regularly and noted significant improvements in their overall fatigue levels (Read Review), while another felt that zinc was crucial for improving various aspects of health related to fatigue (Read Review). Overall, while the right dose wasn't clearly defined, consistent use of zinc emerged as a common approach among users seeking relief from chronic fatigue symptoms.
9
Zinc improves wellbeing
This zinc is fantastic! After a month of use, I've experienced positive changes, especially regarding my chronic fatigue syndrome. My anxiety has lessened, cravings decreased, and my skin and nails have improved significantly. I feel healthier overall!
7.5
Combatting chronic fatigue
I've been taking these vitamins for over a month, and they've really helped with my chronic fatigue syndrome and colds. I would definitely recommend them.
7.5
Increases energy
3 people found this helpful
I suffer from chronic fatigue syndrome and am always looking for energy boosters. Thankfully, I have noticed a definite increase in my energy since using this product. I also love Now Foods products.
9
Significant improvement
I purchased this vitamin for my father, and he noticed considerable improvement in his chronic fatigue syndrome symptoms. It has alleviated bone pain, stress, and fatigue effectively.
7.5
Effective support
4 people found this helpful
This product is very effective for my chronic fatigue syndrome. Whenever I feel fatigued or unwell, I take it, and it significantly helps me feel better.
7
Improved sleep quality
Excellent value for money and quality. Zinc plays a crucial role in our metabolism and boosts immunity. I purchased zinc picolinate alongside other supplements to help with chronic fatigue syndrome, hormone balance, and thyroid function, and it positively impacted my condition. Additionally, magnesium helped manage my restless legs at night, leading to faster sleep and better rest overall. I also bought it for family members to support their recovery from covid. Truly, excellent value and quality.
6
Supports hormonal balance
1 people found this helpful
I take this zinc supplement for polycystic ovary syndrome. It has helped regulate my condition and reduce hair loss. I ensure I follow a consistent schedule for the best results.
7.5
Managing hangover symptoms
I take this zinc to recover from chronic fatigue syndrome and boost my immunity. I’ve noticed that I feel less hungover when I take it regularly, making a significant difference in how I manage my fatigue.
7.5
Essential health supplement
2 people found this helpful
Zinc is crucial for health, especially for issues related to chronic fatigue syndrome. It supports brain function, immunity, and more. Deficiency impacts many aspects of health, particularly in the elderly. I recommend zinc supplementation for its numerous benefits.
7
Zinc supplementation may benefit CFS
Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
7
Zinc's potential benefit in CFS
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.
We conducted a study to explore how zinc, along with other natural substances, impacts chronic fatigue syndrome (CFS). Over a period of 10 to 14 months, we analyzed the levels of specific antibodies in the blood of 41 CFS patients before and after they took a combination of natural anti-inflammatory and antioxidant substances, including zinc, while following a leaky gut diet.
Our findings indicate that zinc may help normalize immune responses related to gut health in CFS patients. Specifically, we saw that as the levels of antibodies related to translocated lipopolysaccharides (LPS) from harmful bacteria normalized, many patients reported clinical improvements. This suggests that gut health is an important factor in managing CFS and that treatments like zinc may play a supportive role.
However, it's important to note that the direct effects of zinc alone cannot be clearly separated from those of other substances taken in the study. The combined approach points to a potential pathway in CFS treatment that emphasizes the role of a healthy gut and could open doors for new drug development targeting gut-related inflammation in CFS patients.
8
Zinc's limited role in fatigue relief
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
9
Zinc may reduce long COVID symptoms
Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
References
Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.